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Endocytic pH‐Triggered Degradation of Nanoengineered Multilayer Capsules
Author(s) -
Liang Kang,
Such Georgina K.,
Johnston Angus P. R.,
Zhu Zhiyuan,
Ejima Hirotaka,
Richardson Joseph J.,
Cui Jiwei,
Caruso Frank
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201305144
Subject(s) - linker , degradation (telecommunications) , materials science , nanotechnology , layer (electronics) , computer science , telecommunications , operating system
The synthesis of cross‐linker free layer‐by‐layer (LbL) capsules that solely utilize cellular pH variations as a trigger to specifically deconstruct and subsequently release cargo in cells is reported. These capsules demonstrate retention of water‐soluble therapeutic molecules as small as 500 Da at extracellular pH. Triggered capsule degradation and release of cargo is observed within 30 min of cell uptake.