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Ratiometric MRI Sensors Based on Core–Shell Nanoparticles for Quantitative pH Imaging
Author(s) -
Okada Satoshi,
Mizukami Shin,
Sakata Takao,
Matsumura Yutaka,
Yoshioka Yoshichika,
Kikuchi Kazuya
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201305018
Subject(s) - materials science , nanoparticle , relaxation (psychology) , core (optical fiber) , scanner , polymer , nanotechnology , particle (ecology) , shell (structure) , computer science , nuclear magnetic resonance , physics , artificial intelligence , medicine , composite material , oceanography , geology
Ratiometric MRI sensors consist of paramagnetic cores and pH‐sensitive polymer shells. The core–shell nanostructure enables the coexistence of two incompatible NMR relaxation properties in one particle. The sensors show pH sensitivity in transverse relaxivity ( r 2 ), but not in longitudinal relaxivity ( r 1 ). Quantitative pH imaging is achieved by measuring the r 2 / r 1 value with a clinical 3 T MRI scanner.