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Peptide‐Tunable Drug Cytotoxicity via One‐Step Assembled Polymer Nanoparticles
Author(s) -
Liang Kang,
Richardson Joseph J.,
Ejima Hirotaka,
Such Georgina K.,
Cui Jiwei,
Caruso Frank
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201305002
Subject(s) - cytotoxicity , materials science , peptide , nanoparticle , dispersity , drug delivery , polymer , nanotechnology , drug , peg ratio , biophysics , chemistry , polymer chemistry , in vitro , pharmacology , biochemistry , composite material , medicine , finance , economics , biology
A novel class of nanoparticles is developed for the co‐delivery of a short cell penetrating peptide and a chemotherapeutic drug to achieve enhanced cytotoxicity. Tunable cytotoxicity is achieved through non‐toxic peptide‐facilitated gating. The strategy relies on a one‐step blending process from polymer building blocks to form monodisperse, PEGylated particles that are sensitive to cellular pH variations. By varying the amount of peptide loading, the chemotherapeutic effects can be enhanced by up to 30‐fold.