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Anchoring Group Effects of Surface Ligands on Magnetic Properties of Fe 3 O 4 Nanoparticles: Towards High Performance MRI Contrast Agents
Author(s) -
Zeng Jianfeng,
Jing Lihong,
Hou Yi,
Jiao Mingxia,
Qiao Ruirui,
Jia Qiaojuan,
Liu Chunyan,
Fang Fang,
Lei Hao,
Gao Mingyuan
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201304744
Subject(s) - anchoring , materials science , nanoparticle , ligand (biochemistry) , saturation (graph theory) , nuclear magnetic resonance , nanotechnology , contrast (vision) , conjugated system , magnetization , magnetic field , polymer , composite material , chemistry , receptor , optics , biochemistry , mathematics , physics , structural engineering , combinatorics , quantum mechanics , engineering
The effect of the anchoring group of surface ligands on the magnetic properties, especially relaxometric properties, of PEGylated Fe 3 O 4 nanoparticles is investigated. Systematic experimental results together with in‐depth theoretical analysis reveal that the ligand binding affinity can largely vary the saturation magnetization, whereas conjugated anchoring groups can remarkably enhance the transverse relaxivity, which highlights a novel approach for achieving high‐performance MRI contrast agents.