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Reversible Non‐Stick Behaviour of a Bacterial Protein Polymer Provides a Tuneable Molecular Mimic for Cell and Tissue Engineering
Author(s) -
Roque Ana I.,
Soliakov Andrei,
Birch Mark A.,
Philips Sion R.,
Shah Deepan S. H.,
Lakey Jeremy H.
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201304645
Subject(s) - extracellular matrix , materials science , polymer , adhesion , bacteria , microbiology and biotechnology , cell adhesion , cell , biophysics , extracellular , tissue engineering , nanotechnology , biology , biochemistry , composite material , genetics
Yersina pestis , the bubonic plague bacterium , is coated with a polymeric protein hydrogel for protection from host defences. The protein, which is robust and non‐stick, resembles structures found in many eukaryotic extracellular‐matrix proteins. Cells grown on the natural polymer cannot adhere and grow poorly; however, when cell‐adhesion motifs are inserted into the protein, the cells proliferate.