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Multicellular Assembly and Light‐Regulation of Cell–Cell Communication by Conjugated Polymer Materials
Author(s) -
Wang Bing,
Song Jinzhao,
Yuan Huanxiang,
Nie Chenyao,
Lv Fengting,
Liu Libing,
Wang Shu
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201304593
Subject(s) - materials science , multicellular organism , cell , conjugated system , polythiophene , reactive oxygen species , biophysics , streptavidin , surface modification , sensitization , nanotechnology , microbiology and biotechnology , polymer , biotin , biochemistry , chemistry , biology , conductive polymer , immunology , composite material
Using cell‐surface modification and biotin–streptavidin interactions, immune cells and target tumor cells are made to form multicellular assemblies. A polythiophene derivative can undergo cellular uptake, allowing the sensitization of oxygen under light irradiation. The subsequent generation of reactive oxygen species (ROS) regulates cell–cell communication in time and space.