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Targeted In Vivo Imaging of Microscopic Tumors with Ferritin‐based Nanoprobes Across Biological Barriers
Author(s) -
Cao Changqian,
Wang Xuxia,
Cai Yao,
Sun Lei,
Tian Lanxiang,
Wu Hao,
He Xiaoqing,
Lei Hao,
Liu Weifeng,
Chen Guanjun,
Zhu Rixiang,
Pan Yongxin
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201304544
Subject(s) - ferritin , materials science , nanoparticle , nanotechnology , in vivo , magnetic resonance imaging , biomedical engineering , nuclear magnetic resonance , biophysics , pathology , biology , medicine , radiology , physics , microbiology and biotechnology
The avascular microscopic breast and brain tumors (<1–2 mm diameter) can be noninvasively detected by designing human heavy‐chain ferritin (HFn)‐based nanoparticles as molecular probes for near‐infrared fluorescence and magnetic resonance imaging. The intravenously injected HFn‐based nanoparticles (Cy5.5–HFn and M–HFn) can cross the endothelium, epithelium, and blood–brain barriers and be internalized into tumor cells.