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Engineered Micro‐Objects as Scaffolding Elements in Cellular Building Blocks for Bottom‐Up Tissue Engineering Approaches
Author(s) -
Leferink A.,
Schipper D.,
Arts E.,
Vrij E.,
Rivron N.,
Karperien M.,
Mittmann K.,
van Blitterswijk C.,
Moroni L.,
Truckenmüller R.
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201304539
Subject(s) - materials science , scaffold , nanotechnology , tissue engineering , wetting , engineering , biomedical engineering , composite material
A material‐based bottom‐up approach is proposed towards an assembly of cells and engineered micro‐objects at the macroscale. We show how shape, size and wettability of engineered micro‐objects play an important role in the behavior of cells on these objects. This approach can, among other applications, be used as a tool to engineer complex 3D tissues of clinically relevant size.