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DNA‐mediated Construction of Hollow Upconversion Nanoparticles for Protein Harvesting and Near‐Infrared Light Triggered Release
Author(s) -
Zhou Li,
Chen Zhaowei,
Dong Kai,
Yin Meili,
Ren Jinsong,
Qu Xiaogang
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201304437
Subject(s) - materials science , photon upconversion , nanotechnology , dna , nanoparticle , intracellular , enzyme , biophysics , in vitro , infrared , optoelectronics , biochemistry , biology , luminescence , optics , physics
A simple DNA‐mediated solvothermal method has been developed for the construction of well‐defined hollow UNPs that can be used for a new paradigm to realize NIR light‐controlled non‐invasive protein release. In vitro studies show that the UNPs are capable of the transportation of enzyme into living cells. Intracellular NIR triggers the release of enzymes with high spatial and temporal precision and the released enzyme also retains its biological activity.