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Macromolecular Crowding Meets Tissue Engineering by Self‐Assembly: A Paradigm Shift in Regenerative Medicine
Author(s) -
Satyam Abhigyan,
Kumar Pramod,
Fan Xingliang,
Gorelov Alexander,
Rochev Yury,
Joshi Lokesh,
Peinado Héctor,
Lyden David,
Thomas Benjamin,
Rodriguez Brian,
Raghunath Michael,
Pandit Abhay,
Zeugolis Dimitrios
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201304428
Subject(s) - macromolecular crowding , regenerative medicine , materials science , macromolecule , tissue engineering , nanotechnology , inert , biophysics , biomedical engineering , microbiology and biotechnology , stem cell , chemistry , biology , biochemistry , organic chemistry , engineering
MMC, the addition of inert polydispersed macromolecules in the culture media , effectively emulates the dense in vivo extracellular space, resulting in amplified deposition of ECM in vitro and subsequent production of cohesive, ECM‐rich living substitutes.