Premium
Biophysically Defined and Cytocompatible Covalently Adaptable Networks as Viscoelastic 3D Cell Culture Systems
Author(s) -
McKin Daniel D.,
Domaille Dylan W.,
Cha Jennifer N.,
Anseth Kristi S.
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201303680
Subject(s) - viscoelasticity , stress relaxation , materials science , covalent bond , computer science , nanotechnology , tissue engineering , content delivery , cell encapsulation , encapsulation (networking) , self healing hydrogels , biomedical engineering , composite material , polymer chemistry , chemistry , medicine , creep , organic chemistry , computer network
Presented here is a cytocompatible covalently adaptable hydrogel uniquely capable of mimicking the complex biophysical properties of native tissue and enabling natural cell functions without matrix degradation. Demonstrated is both the ability to control elastic modulus and stress relaxation time constants by more than an order of magnitude while predicting these values based on fundamental theoretical understanding and the simulation of muscle tissue and the encapsulation of myoblasts.