Premium
Proteoglycans and Glycosaminoglycans Improve Toughness of Biocompatible Double Network Hydrogels
Author(s) -
Zhao Yu,
Nakajima Tasuku,
Yang Jing Jing,
Kurokawa Takayuki,
Liu Jian,
Lu Jishun,
Mizumoto Shuji,
Sugahara Kazuyuki,
Kitamura Nobuto,
Yasuda Kazunori,
Daniels A. U. D.,
Gong Jian Ping
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201303387
Subject(s) - self healing hydrogels , materials science , biocompatible material , chondroitin sulfate , biopolymer , hyaluronic acid , glycosaminoglycan , polymer , polypyrrole , toughness , chemical engineering , nanotechnology , polymer science , biomedical engineering , polymer chemistry , composite material , chemistry , biochemistry , polymerization , anatomy , medicine , engineering
Based on the molecular stent concept , a series of tough double‐network hydrogels (St‐DN gels) made from the components of proteoglycan aggregates – chondroitin sulfate proteoglycans (1), chondroitin sulfate (2), and sodium hyaluronate (3) – are successfully developed in combination with a neutral biocompatible polymer. This work demonstrates a promising method to create biopolymer‐based tough hydrogels for biomedical applications.