Rational Design of Polyion Complex Nanoparticles to Overcome Cisplatin Resistance in Cancer Therapy | Zendy

Yang XianZhu | Zendy; Du XiaoJiao | Zendy; Liu Yang | Zendy; Zhu YanHua | Zendy; Liu YangZhong | Zendy; Li YaPing | Zendy; Wang Jun | Zendy

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Rational Design of Polyion Complex Nanoparticles to Overcome Cisplatin Resistance in Cancer Therapy

Author(s) -

Yang XianZhu,

Du XiaoJiao,

Liu Yang,

Zhu YanHua,

Liu YangZhong,

Li YaPing,

Wang Jun

Publication year - 2014

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.201303360

Subject(s) - cisplatin , nanoparticle , rational design , drug delivery , nanotechnology , cancer therapy , tumor cells , content delivery , computer science , materials science , cancer research , cancer , biology , chemotherapy , computer network , genetics

Rationally designed PIC nanoparticles as next‐generation delivery system : we have developed a core–shell–corona PIC nanoparticle ⊕ NP/Pt@PPC‐DA as a next‐generation delivery system. ⊕ NP/Pt@PPC‐DA exhibits prolonged circulation and enhanced drug accumulation in tumors. Subsequently, tumor pH leads to the release of ⊕ NP/Pt, which facilitates cellular uptake followed by rapid intracellular cisplatin release. Using this delivery strategy cisplatin‐resistant tumor growth in a murine xenograft model has been successfully suppressed.

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