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Rational Design of Polyion Complex Nanoparticles to Overcome Cisplatin Resistance in Cancer Therapy
Author(s) -
Yang XianZhu,
Du XiaoJiao,
Liu Yang,
Zhu YanHua,
Liu YangZhong,
Li YaPing,
Wang Jun
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201303360
Subject(s) - cisplatin , nanoparticle , rational design , drug delivery , nanotechnology , cancer therapy , tumor cells , content delivery , computer science , materials science , cancer research , cancer , biology , chemotherapy , computer network , genetics
Rationally designed PIC nanoparticles as next‐generation delivery system : we have developed a core–shell–corona PIC nanoparticle ⊕ NP/Pt@PPC‐DA as a next‐generation delivery system. ⊕ NP/Pt@PPC‐DA exhibits prolonged circulation and enhanced drug accumulation in tumors. Subsequently, tumor pH leads to the release of ⊕ NP/Pt, which facilitates cellular uptake followed by rapid intracellular cisplatin release. Using this delivery strategy cisplatin‐resistant tumor growth in a murine xenograft model has been successfully suppressed.