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Fabrication of Cysteine‐Responsive Biomimetic Single Nanochannels by a Thiol‐yne Reaction Strategy and Their Application for Sensing in Urine Samples
Author(s) -
Sun Zhongyue,
Han Cuiping,
Song Miaomiao,
Wen Long,
Tian Demei,
Li Haibing,
Jiang Lei
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201303158
Subject(s) - nanotechnology , fabrication , thiol , materials science , click chemistry , covalent bond , cysteine , combinatorial chemistry , computer science , chemistry , organic chemistry , alternative medicine , pathology , enzyme , medicine
A photoinitiated thiol‐yne click reaction strategy is used to fabricate a novel responsive biomimetic nanochannel platform. It displays a selective response for Cys by way of covalent bond formation on the channel surface. This system can be applied for Cys sensing with high specificity and non‐interference performance in complex matrices and human urine samples.