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Polyphosphoester‐Based Cationic Nanoparticles Serendipitously Release Integral Biologically‐Active Components to Serve as Novel Degradable Inducible Nitric Oxide Synthase Inhibitors
Author(s) -
Shen Yuefei,
Zhang Shiyi,
Zhang Fuwu,
Loftis Alexander,
PavíaSanders Adriana,
Zou Jiong,
Fan Jingwei,
Taylor JohnStephen A.,
Wooley Karen L.
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201302842
Subject(s) - nitric oxide , nitric oxide synthase , cationic polymerization , pharmacology , materials science , nanoparticle , drug , drug delivery , biochemistry , nanotechnology , biophysics , chemistry , medicine , biology , organic chemistry , polymer chemistry
A degradable polyphosphoester (PPE)‐based cationic nanoparticle (cSCK) , which is integrated constructed as a novel degradable drug device, demonstrates surprisingly efficient inhibition of inducible nitric oxide synthase (iNOS) transcription, and eventually inhibits nitric oxide (NO) over‐production, without loading of any specific therapeutic drugs. This system may serve as a promising anti‐inflammatory agent toward the treatment of acute lung injury.