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Multifunctional Plasmonic Nanorattles for Spectrum‐Guided Locoregional Therapy
Author(s) -
Gandra Naveen,
Portz Christopher,
Singamaneni Srikanth
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201302803
Subject(s) - payload (computing) , raman spectroscopy , nanotechnology , materials science , raman scattering , plasmon , process (computing) , service (business) , drug delivery , computer science , optoelectronics , optics , physics , computer network , economy , economics , operating system , network packet
Locoregional death of cancer cells (in vitro) is induced by ablation of plasmonic nanorattles combined with triggered release of a chemotherapeutic drug from the nanorattles. Completion of the therapy process is indicated by a “Raman signal flip” between the two reporters of the surface‐enhanced Raman scattering (SERS) probe. The nanorattles enable targeted delivery of payload and simultaneous monitoring of the payload release and the therapy process.