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Three‐Dimensional Microscaffolds Exhibiting Spatially Resolved Surface Chemistry
Author(s) -
Richter Benjamin,
Pauloehrl Thomas,
Kaschke Johannes,
Fichtner Dagmar,
Fischer Joachim,
Greiner Alexandra M.,
Wedlich Doris,
Wegener Martin,
Delaittre Guillaume,
BarnerKowollik Christopher,
Bastmeyer Martin
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201302678
Subject(s) - silanization , bioconjugation , femtosecond , fluorescence , materials science , cycloaddition , surface (topology) , nanotechnology , laser , surface modification , chemistry , organic chemistry , optics , catalysis , physics , geometry , mathematics , composite material
Spatial control over the surface chemistry of 3D organic–inorganic hybrid microscaffolds is achieved by a two‐photon‐triggered cycloaddition. Following a coating step with photoactivatable dienes via silanization, surface irradiation with a femtosecond‐pulsed laser in the presence of functional dienophiles enables a site‐selective alteration of the surface chemistry. Bioconjugation with fluorescent protein tags is employed to reveal the 3D molecular patterns.