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Enhanced Efficacy of Superparamagnetic Iron Oxide Nanoparticles Against Antibiotic‐Resistant Biofilms in the Presence of Metabolites
Author(s) -
Durmus Naside G.,
Taylor Erik N.,
Kummer Kim M.,
Webster Thomas J.
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201302627
Subject(s) - biofilm , antibiotics , materials science , nanotechnology , superparamagnetism , bacteria , antibiotic resistance , nanoparticle , microbiology and biotechnology , biology , genetics , magnetization , physics , quantum mechanics , magnetic field
Antibiotic resistance and the lack of new antibacterial agents cause major challenges for the treatment of infections. Here, we describe a simple, broad‐spectrum, and low‐cost dual‐sided approach which uses superparamagnetic iron oxide particles (SPION) in combination with fructose metabolites as an alternative to existing antibacterial strategies. This strategy offers further improved efficacy of SPION against persistent gram‐positive and gram‐negative bacteria infections by manipulating the biofilm metabolic microenvironment and outperforms vancomycin (the antibiotic of last resort), creating a new nanotechnology‐driven approach.