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A Selective Artificial Enzyme Inhibitor Based on Nanoparticle‐Enzyme Interactions and Molecular Imprinting
Author(s) -
Zheng Cheng,
Zhang XiaoLong,
Liu Wei,
Liu Bo,
Yang HuangHao,
Lin ZiAn,
Chen GuoNan
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201302064
Subject(s) - imprinting (psychology) , molecular imprinting , enzyme , nanoparticle , nanotechnology , computational biology , materials science , artificial cell , combinatorial chemistry , computer science , biochemistry , biology , selectivity , gene , chemistry , membrane , catalysis
A novel and general strategy is developed to design selective artificial enzyme inhibitor based on nanoparticleenzyme inter actions and molecular imprinting. Due to the creation of specific binding cavities, the resulting artificial inhibitor has high inhibition efficiency for the target enzyme, and shows great target‐selectivity over other enzymes of similar function and proteins of compaable mole cular weight.