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Ultrabright Organic Dots with Aggregation‐Induced Emission Characteristics for Real‐Time Two‐Photon Intravital Vasculature Imaging
Author(s) -
Ding Dan,
Goh Chi Ching,
Feng Guangxue,
Zhao Zujin,
Liu Jie,
Liu Rongrong,
Tomczak Nikodem,
Geng Junlong,
Tang Ben Zhong,
Ng Lai Guan,
Liu Bin
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201301938
Subject(s) - quantum dot , aggregation induced emission , in vivo , nanotechnology , materials science , photon , absorption (acoustics) , quantum yield , two photon excitation microscopy , computer science , optics , physics , fluorescence , biology , microbiology and biotechnology , composite material
Ultrabright organic dots with aggregation‐induced emission characteristics (AIE dots) are prepared and shown to exhibit a high quantum yield, a, large two‐photon absorption cross‐section, and low in vivo toxicity. Real‐time two‐photon intravital blood vascular imaging in various tissues substantiates that the AIE dots are effective probes for in vivo vasculature imaging in a deep and high‐contrast manner.