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Lipid‐Modified Aminoglycoside Derivatives for In Vivo siRNA Delivery
Author(s) -
Zhang Yunlong,
Pelet Jeisa M.,
Heller Daniel A.,
Dong Yizhou,
Chen Delai,
Gu Zhen,
Joseph Brian J.,
Wallas Jasmine,
Anderson Daniel G.
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201301917
Subject(s) - in vivo , gene knockdown , materials science , aminoglycoside , in vitro , nanoparticle , rna interference , nanotechnology , small interfering rna , gene delivery , biophysics , pharmacology , biochemistry , biology , rna , gene , genetic enhancement , antibiotics , microbiology and biotechnology
Rationally designed siRNA delivery materials that are enabled by lipid‐modified aminoglycosides are demonstrated. Leading materials identified are able to self‐assemble with siRNA into well‐defined nanoparticles and induce efficient gene knockdown both in vitro and in vivo. Histology studies and liver function tests reveal that no apparent toxicity is caused by these nanoparticles at doses over two orders of magnitude.