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Rational Design of Multifunctional Upconversion Nanocrystals/Polymer Nanocomposites for Cisplatin (IV) Delivery and Biomedical Imaging
Author(s) -
Ma Ping'an,
Xiao Haihua,
Li Xiaoxue,
Li Chunxia,
Dai Yunlu,
Cheng Ziyong,
Jing Xiabin,
Lin Jun
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201301713
Subject(s) - materials science , photon upconversion , nanotechnology , cisplatin , prodrug , nanoparticle , rational design , in vivo , drug delivery , nanocomposite , polymer , copolymer , luminescence , optoelectronics , chemistry , chemotherapy , medicine , biochemistry , surgery , microbiology and biotechnology , composite material , biology
By combining upconversion nanoparticles with the cisplatin (IV) prodrug we have demonstrated that a stable and multifunctional drug delivery system can be designed that will both reduce the drawbacks of cisplatin and give insight in to its in vitro/in vivo imaging. The up/down‐conversion fluorescence are detectable and show obvious co‐localization, demonstrating that the nanoparticles are rather stable inside cells and retain the UCNPs and block copolymer.