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Tuning of Cell–Biomaterial Anchorage for Tissue Regeneration
Author(s) -
LealEgaña Aldo,
DíazCuenca Aránzazu,
Boccaccini Aldo R.
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201301227
Subject(s) - biomaterial , materials science , extracellular matrix , regeneration (biology) , wetting , biocompatible material , tissue engineering , cell , nanotechnology , matrix (chemical analysis) , cell function , cell adhesion , biophysics , biomedical engineering , microbiology and biotechnology , adhesion , chemistry , composite material , biology , biochemistry , engineering
Which mechanisms mediate cell attachment to biomaterials? What role does the surface charge or wettability play on cell–material anchorage? What are the currently investigated strategies to modify cell–matrix adherence spatiotemporally? Considering the development of scaffolds made of biocompatible materials to temporarily replace the structure and/or function of the extracellular matrix, focus is given to the analysis of the specific (i.e., cell adhesive peptide sequences) and unspecific (i.e., surface charge, wettability) mechanisms mediating cell‐matrix interactions. Furthermore, because natural tissue regeneration is characterized by the dynamic attachment/detachment of different cell populations, the design of advanced scaffolds for tissue engineering, based in the spatiotemporal tuning of cell–matrix anchorage is discussed.