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LHRH‐PE40 Fusion Protein Tethered Silica Nanorattles for Imaging‐Guided Tumor‐Specific Drug Delivery and Bimodal Therapy
Author(s) -
Gao Fuping,
Li Linlin,
Fu Changhui,
Nie Liya,
Chen Dong,
Tang Fangqiong
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201301217
Subject(s) - docetaxel , drug delivery , drug , materials science , fusion protein , cancer research , targeted drug delivery , cancer therapy , biomedical engineering , cancer , biophysics , nanotechnology , pharmacology , medicine , chemistry , biochemistry , biology , recombinant dna , gene
Docyanine green (ICG) and LHRH‐PE40 fusion protein are tethered onto drug carriers of silica nanorattles for imaging‐guided tumor‐specific drug delivery and bimodal therapy. The synergistic therapeutic effect of toxin PE40 and the chemotherapeutic drug docetaxel (Dtxl), specifically directed by LHRH to cancer, improves cancer treatment. Simultaneously, ICG enables real‐time monitoring of the silica nanocomposites and therapeutic response.