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Crystalline Calcium Alendronate Obtained by Octacalcium Phosphate Digestion: A New Chance for Local Treatment of Bone Loss Diseases?
Author(s) -
Boanini Elisa,
Torricelli Paola,
Gazzano Massimo,
Fini Milena,
Bigi Adriana
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201301129
Subject(s) - octacalcium phosphate , calcium , osteoclast , materials science , bisphosphonate , osteoblast , phosphate , precipitation , chemical engineering , chemistry , biochemistry , medicine , osteoporosis , in vitro , metallurgy , engineering , physics , meteorology
Octacalcium phosphate (OCP) interaction with alendronate (AL) solution results in the complete digestion of OCP: calcium ion is recruited by the bisphosphonate to yield quantitative precipitation of crystalline calcium alendronate monohydrate. This compound improves osteoblast differentiation and inhibits osteoclast proliferation and activity, both alone and, even more, in combination with OCP.