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Cell‐laden Microengineered and Mechanically Tunable Hybrid Hydrogels of Gelatin and Graphene Oxide
Author(s) -
Shin Su Ryon,
AghaeiGharehBolagh Behnaz,
Dang Tram T.,
Topkaya Seda Nur,
Gao Xiguang,
Yang Seung Yun,
Jung Sung Mi,
Oh Jong Hyun,
Dokmeci Mehmet R.,
Tang Xiaowu Shirley,
Khademhosseini Ali
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201301082
Subject(s) - self healing hydrogels , graphene , materials science , gelatin , nanotechnology , oxide , stacking , tissue engineering , biomedical engineering , polymer chemistry , chemistry , engineering , biochemistry , organic chemistry , metallurgy
Incorporating graphene oxide inside GelMA hydrogels enhances their mechanical properties and reduces UV‐induced cell damage while preserving their favorable characteristics for 3D cell encapsulation. NIH‐3T3 fibroblasts encapsulated in GO‐GelMA microgels demonstrate excellent cellular viability, proliferation, spreading, and alignment. GO reinforcement combined with a multi‐stacking approach offers a facile engineering strategy for the construction of complex artificial tissues.