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Non‐Invasive Synergistic Treatment of Brain Tumors by Targeted Chemotherapeutic Delivery and Amplified Focused Ultrasound‐Hyperthermia Using Magnetic Nanographene Oxide
Author(s) -
Yang HungWei,
Hua MuYi,
Hwang TsongLong,
Lin KunJu,
Huang ChiungYin,
Tsai RungYwan,
Ma ChenChi M.,
Hsu PoHung,
Wey ShiawPyng,
Hsu PengWei,
Chen PinYuan,
Huang YinCheng,
Lu YuJen,
Yen TzuChen,
Feng LiYing,
Lin ChihWen,
Liu HaoLi,
Wei KuoChen
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201301046
Subject(s) - nanocarriers , hyperthermia , materials science , magnetic hyperthermia , drug delivery , cancer research , absorption (acoustics) , chemotherapeutic drugs , ultrasound , brain tumor , biomedical engineering , nanotechnology , magnetic nanoparticles , nanoparticle , medicine , chemotherapy , pathology , radiology , surgery , composite material
The combination of chemo‐thermal therapy is the best strategy to ablate tumors , but how to heat deep tumor tissues effectively without side‐damage is a challenge. Here, a systemically delivered nanocarrier is designed with multiple advantages, including superior heat absorption, highly efficient hyperthermia, high drug capacity, specific targeting ability, and molecular imaging, to achieve both high antitumor efficacy and effective amplification of hyperthermia with minimal side effects.