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Bioactive Silicate Nanoplatelets for Osteogenic Differentiation of Human Mesenchymal Stem Cells
Author(s) -
Gaharwar Akhilesh K.,
Mihaila Silvia M.,
Swami Archana,
Patel Alpesh,
Sant Shilpa,
Reis Rui L.,
Marques Alexandra P.,
Gomes Manuela E.,
Khademhosseini Ali
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201300584
Subject(s) - mesenchymal stem cell , materials science , silicate , stem cell , tissue engineering , nanotechnology , microbiology and biotechnology , biomedical engineering , biophysics , chemical engineering , biology , medicine , engineering
Novel silicate nanoplatelets that induce osteogenic differentiation of human mesenchymal stem cells (hMSCs) in the absence of any osteoinductive factor are reported. The presence of the silicate triggers a set of events that follows the temporal pattern of osteogenic differentiation. These findings underscore the potential applications of these silicate nanoplatelets in designing bioactive scaffolds for musculoskeletal tissue engineering.