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Diamond‐Lipid Hybrids Enhance Chemotherapeutic Tolerance and Mediate Tumor Regression
Author(s) -
Moore Laura,
Chow Edward KaiHua,
Osawa Eiji,
Bishop J. Michael,
Ho Dean
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201300343
Subject(s) - nanodiamond , materials science , epirubicin , cancer research , nanotechnology , diamond , biology , cancer , breast cancer , medicine , composite material
Self‐assembled nanodiamond‐lipid hybrid particles (NDLPs) harness the potent interaction between the nanodiamond (ND)‐surface and small molecules, while providing a mechanism for cell‐targeted imaging and therapy of triple negative breast cancers. Epidermal growth factor receptor‐targeted NDLPs are highly biocompatible particles that provide cell‐specific imaging, promote tumor retention of ND‐complexes, prevent epirubicin toxicities and mediate regression of triple negative breast cancers.