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Recombinant Supercharged Polypeptides Restore and Improve Biolubrication
Author(s) -
Veeregowda Deepak H.,
Kolbe Anke,
van der Mei Henny C.,
Busscher Henk J.,
Herrmann Andreas,
Sharma Prashant K.
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201300188
Subject(s) - materials science , recombinant dna , adsorption , nanotechnology , mucin , lubrication , biophysics , composite material , chemistry , biochemistry , biology , gene
Recombinant supercharged polypeptides (SUPs) with low cytotoxicity are developed and applied to rejuvenate the lubrication of naturally occurring salivary conditioning films (SCFs). SUPs with 72 positive charges adsorbed and rigidified the SCFs and recruited mucins to form a hydrated layer. These SCFs with SUPs have higher mechanical strength and sustain lubricating effect for longer duration compared with only SCFs.