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Specific Capture and Release of Circulating Tumor Cells Using Aptamer‐Modified Nanosubstrates
Author(s) -
Shen Qinglin,
Xu Li,
Zhao Libo,
Wu Dongxia,
Fan Yunshan,
Zhou Yiliang,
OuYang WeiHan,
Xu Xiaochun,
Zhang Zhen,
Song Min,
Lee Tom,
Garcia Mitch A.,
Xiong Bin,
Hou Shuang,
Tseng HsianRong,
Fang Xiaohong
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201300082
Subject(s) - aptamer , circulating tumor cell , materials science , systematic evolution of ligands by exponential enrichment , dna , nanotechnology , silicon nanowires , selex aptamer technique , biophysics , cancer research , microbiology and biotechnology , cancer , biology , nanowire , biochemistry , rna , genetics , metastasis , gene
A platform for capture and release of circulating tumor cells (CTCs) is demonstrated by utilizing aptamer grafted silicon nanowires. Here, single‐stranded DNA‐aptamers are generated via the Cell‐SELEX process to serve as capture agents, allowing specific capture and release of non‐small cell lung cancer (NSCLC) CTCs from whole‐blood samples with minimum contamination and negligible disruption to CTC viability and functions.