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Micropatterning: Tomography and Static‐Mechanical Properties of Adherent Cells (Adv. Mater. 42/2012)
Author(s) -
Soh Siowling,
KandereGrzybowska Kristiana,
Mahmud Goher,
Huda Sabil,
Patashinski Alexander Z.,
Grzybowski Bartosz A.
Publication year - 2012
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201290263
Subject(s) - micropatterning , materials science , nucleus , tomography , membrane , actin , cell , biophysics , biomedical engineering , nanotechnology , optics , microbiology and biotechnology , chemistry , biology , physics , medicine , biochemistry
A tomography approach is used to reconstruct 3D cell shapes and the shapes/positions of the nuclei within these cells simultaneously. Bartosz A. Grzybowski, Kristiana Kandere‐Grzybowska and co‐workers show on page 5719 that cells subjected to well‐defined microconfinements of various diameters allow for relating the steady‐state shapes of cells to their staticmechanical properties. The observed shapes show striking regularities between different cell types and all fit to a model that takes into account the cell membrane, cortical actin, and the nucleus.