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Tissue Engineering: The Design of a Heterocellular 3D Architecture and its Application to Monitoring the Behavior of Cancer Cells in Response to the Spatial Distribution of Endothelial Cells (Adv. Mater. 39/2012)
Author(s) -
Lee Wonjae,
Park Jon
Publication year - 2012
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201290241
Subject(s) - materials science , stacking , nanotechnology , tissue engineering , biophysics , biomedical engineering , biology , chemistry , medicine , organic chemistry
Spatial cell distribution is one of the critical features for governing cellular interactions and subsequent cell behaviors. On page 5339 , Jon Park and Wonjae Lee suggest a novel method to build a 3D hierarchical cellular structure by stacking cell‐attached micro plate structures with specific configurations within hydrogel layers. As a model system, the 3D architecture of a liver lobule, a structural unit of the liver, was reconstructed (red: hepatocytes in a hydrogel layer, green: endothelial cells on a micro plate structure) in which the desired heterocellular interactions were successfully restored.