Tissue Engineering: The Design of a Heterocellular 3D Architecture and its Application to Monitoring the Behavior of Cancer Cells in Response to the Spatial Distribution of Endothelial Cells (Adv. Mater. 39/2012) | Zendy

Lee Wonjae | Zendy; Park Jon | Zendy

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Tissue Engineering: The Design of a Heterocellular 3D Architecture and its Application to Monitoring the Behavior of Cancer Cells in Response to the Spatial Distribution of Endothelial Cells (Adv. Mater. 39/2012)

Author(s) -

Lee Wonjae,

Park Jon

Publication year - 2012

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.201290241

Subject(s) - materials science , stacking , nanotechnology , tissue engineering , biophysics , biomedical engineering , biology , chemistry , medicine , organic chemistry

Spatial cell distribution is one of the critical features for governing cellular interactions and subsequent cell behaviors. On page 5339 , Jon Park and Wonjae Lee suggest a novel method to build a 3D hierarchical cellular structure by stacking cell‐attached micro plate structures with specific configurations within hydrogel layers. As a model system, the 3D architecture of a liver lobule, a structural unit of the liver, was reconstructed (red: hepatocytes in a hydrogel layer, green: endothelial cells on a micro plate structure) in which the desired heterocellular interactions were successfully restored.

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