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Lipid Nanoparticles: Peptide Targeted Lipid Nanoparticles for Anticancer Drug Delivery (Adv. Mater. 28/2012)
Author(s) -
Pearce Timothy R.,
Shroff Kamlesh,
Kokkoli Efrosini
Publication year - 2012
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201290171
Subject(s) - internalization , nanoparticle , drug delivery , peptide , materials science , targeted drug delivery , nanotechnology , cancer research , receptor , biophysics , medicine , chemistry , biochemistry , biology
Nanoparticles reach the tumor through the “leaky” tumor vasculature that allows the transfer of large molecules out of the blood stream. Once in the tumor microenvironment targeting peptides on the surface of the nanoparticles allow specific binding by tumor‐cell receptors and subsequent cell internalization. On page 3803 , E. Kokkoli and co‐workers review the recent strategies used to create peptide‐targeted lipid nano‐particles to improve cancer therapy.