Drug Delivery: Multistage pH‐Responsive Liposomes for Mitochondrial‐Targeted Anticancer Drug Delivery (Adv. Mater. 27/2012) | Zendy

Mo Ran | Zendy; Sun Qiong | Zendy; Xue Jingwei | Zendy; Li Nan | Zendy; Li Wenyuan | Zendy; Zhang Can | Zendy; Ping Qineng | Zendy

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Drug Delivery: Multistage pH‐Responsive Liposomes for Mitochondrial‐Targeted Anticancer Drug Delivery (Adv. Mater. 27/2012)

Author(s) -

Mo Ran,

Sun Qiong,

Xue Jingwei,

Li Nan,

Li Wenyuan,

Zhang Can,

Ping Qineng

Publication year - 2012

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.201290167

Subject(s) - liposome , drug delivery , mitochondrion , intracellular , drug , drug carrier , targeted drug delivery , pharmacology , biophysics , materials science , biochemistry , chemistry , biology , nanotechnology

Liposomes with multistage pH‐response to a mildly acidic tumor extracellular matrix and acidic intracellular compartments are like rockets for transporting anticancer drugs to mitochondria, as reported by C. Zhang and co‐workers. On page 3659 , liposomes reverse the charge of the tumor microenvironment, enhancing cellular uptake (white flying rocket), escape from endolysosomes (blue sphere), and delivery to mitochondria in tumor cells (black flying rocket), providing a safe, efficient carrier platform for cascade drug delivery on the basis of a kinetic process.

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