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Drug Delivery: Multistage pH‐Responsive Liposomes for Mitochondrial‐Targeted Anticancer Drug Delivery (Adv. Mater. 27/2012)
Author(s) -
Mo Ran,
Sun Qiong,
Xue Jingwei,
Li Nan,
Li Wenyuan,
Zhang Can,
Ping Qineng
Publication year - 2012
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201290167
Subject(s) - liposome , drug delivery , mitochondrion , drug , intracellular , drug carrier , targeted drug delivery , materials science , biophysics , pharmacology , nanotechnology , biochemistry , chemistry , biology
Liposomes with multistage pH‐response to a mildly acidic tumor extracellular matrix and acidic intracellular compartments are like rockets for transporting anticancer drugs to mitochondria, as reported by C. Zhang and co‐workers. On page 3659 , liposomes reverse the charge of the tumor microenvironment, enhancing cellular uptake (white flying rocket), escape from endolysosomes (blue sphere), and delivery to mitochondria in tumor cells (black flying rocket), providing a safe, efficient carrier platform for cascade drug delivery on the basis of a kinetic process.