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Drug Delivery: Near‐Infrared Light‐Responsive Intracellular Drug and siRNA Release Using Au Nanoensembles with Oligonucleotide‐Capped Silica Shell (Adv. Mater. 25/2012)
Author(s) -
Chang YiTing,
Liao PeiYi,
Sheu HwoShuenn,
Tseng YuJui,
Cheng FongYu,
Yeh ChenSheng
Publication year - 2012
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201290153
Subject(s) - oligonucleotide , materials science , drug delivery , nanotechnology , intracellular , nanorod , drug , diode , biophysics , dna , optoelectronics , chemistry , pharmacology , biochemistry , medicine , biology
NIR‐responsive oligonucleotide‐gated ensembles are developed on page 3309 by F.‐Y. Cheng, C.‐S. Yeh, and co‐workers for intracellular drug delivery. Taking advantage of the NIR‐absorbing character of gold nanorods, a CW NIR diode laser is employed to control cargo and drug release through the thermal dehybridization of duplex oligonucleotides. This design has great therapeutic potential, with capabilities for siRNA delivery into cells for translational regulation as well as for cytotoxcitity through anti‐cancer drug delivery.