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Patterning: Three‐Dimensional Biomimetic Patterning in Hydrogels to Guide Cellular Organization (Adv. Mater. 17/2012)
Author(s) -
Culver James C.,
Hoffmann Joseph C.,
Poché Ross A.,
Slater John H.,
West Jennifer L.,
Dickinson Mary E.
Publication year - 2012
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201290096
Subject(s) - self healing hydrogels , materials science , nanotechnology , tissue engineering , ethylene glycol , photolithography , biomedical engineering , chemical engineering , polymer chemistry , engineering
On page 2344 , J. L. West, M. E. Dickinson, and co‐workers demonstrate an image‐guided method for engineering complex biomimetic materials. Using laser scanning microscopes and twophoton photolithography, they use this method to create patterned poly(ethylene glycol) diacrylate hydrogels that recreate 3D structural and biochemical features of endogenous vascular microenvironments, as shown here for the coronary vasculature. These biomaterials can effectively guide cellular organization in order to recapitulate endogenous vascular structures, marking an important step forward for tissue engineering.