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High‐Purity Prostate Circulating Tumor Cell Isolation by a Polymer Nanofiber‐Embedded Microchip for Whole Exome Sequencing
Author(s) -
Zhao Libo,
Lu YiTsung,
Li Fuqiang,
Wu Kui,
Hou Shuang,
Yu Juehua,
Shen Qinglin,
Wu Dongxia,
Song Min,
OuYang WeiHan,
Luo Zheng,
Lee Tom,
Fang Xiaohong,
Shao Chen,
Xu Xun,
Garcia Mitch A.,
Chung Leland W. K.,
Rettig Matthew,
Tseng HsianRong,
Posadas Edwin M.
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201205237
Subject(s) - circulating tumor cell , laser capture microdissection , materials science , prostate cancer , exome sequencing , nanofiber , nanotechnology , computational biology , cancer research , cancer , biology , gene , genetics , mutation , metastasis , gene expression
Handpick single cancer cells: A modified NanoVelcro Chip is coupled with ArcturusXT laser capture microdissection (LCM) technology to enable the detection and isolation of single circulating tumor cells (CTCs) from patients with prostate cancer (PC). This new approach paves the way for conducting next‐generation sequencing (NGS) on single CTCs.