Oxime Cross‐Linked Injectable Hydrogels for Catheter Delivery | Zendy

Grover Gregory N. | Zendy; Braden Rebecca L. | Zendy; Christman Karen L. | Zendy

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Oxime Cross‐Linked Injectable Hydrogels for Catheter Delivery

Author(s) -

Grover Gregory N.,

Braden Rebecca L.,

Christman Karen L.

Publication year - 2013

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.201205234

Subject(s) - self healing hydrogels , materials science , catheter , mixing (physics) , delivery system , oxime , biomedical engineering , nanotechnology , chemical engineering , surgery , polymer chemistry , organic chemistry , medicine , chemistry , physics , quantum mechanics , engineering

Catheter delivery of therapeutic materials is important for developing minimally invasive treatment approaches. However, the majority of injectable materials gel rapidly upon mixing and/or heating to body temperature. The application of an oxime cross‐linked hydrogel system is demonstrated. The system has a broad range of tunable gelation rates, is capable of injection through a catheter, and exhibits rapid gelation upon injection into tissue.

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