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Oxime Cross‐Linked Injectable Hydrogels for Catheter Delivery
Author(s) -
Grover Gregory N.,
Braden Rebecca L.,
Christman Karen L.
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201205234
Subject(s) - self healing hydrogels , materials science , catheter , mixing (physics) , delivery system , oxime , biomedical engineering , nanotechnology , chemical engineering , surgery , polymer chemistry , organic chemistry , medicine , chemistry , physics , quantum mechanics , engineering
Catheter delivery of therapeutic materials is important for developing minimally invasive treatment approaches. However, the majority of injectable materials gel rapidly upon mixing and/or heating to body temperature. The application of an oxime cross‐linked hydrogel system is demonstrated. The system has a broad range of tunable gelation rates, is capable of injection through a catheter, and exhibits rapid gelation upon injection into tissue.