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Non‐Viral Gene Delivery via Membrane‐Penetrating, Mannose‐Targeting Supramolecular Self‐Assembled Nanocomplexes
Author(s) -
Yin Lichen,
Song Ziyuan,
Kim Kyung Hoon,
Zheng Nan,
Gabrielson Nathan P.,
Cheng Jianjun
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201205088
Subject(s) - georgia tech , library science , science and engineering , nanotechnology , engineering , engineering physics , materials science , computer science , engineering ethics
Supramolecular self‐assembled nanocomplexes (SSANs) capable of mannose receptor‐mediated endocytosis and permeable to cellular and endosomal membranes are developed via the assembly of multiple rationally designed, function‐specific materials. As a unique non‐viral gene delivery vector, SSANs outperform commercial transfection reagents, including LPF2000, PEI, and jetPEI, by up to 2 orders of magnitude.