Non‐Viral Gene Delivery via Membrane‐Penetrating, Mannose‐Targeting Supramolecular Self‐Assembled Nanocomplexes | Zendy

Yin Lichen | Zendy; Song Ziyuan | Zendy; Kim Kyung Hoon | Zendy; Zheng Nan | Zendy; Gabrielson Nathan P. | Zendy; Cheng Jianjun | Zendy

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Non‐Viral Gene Delivery via Membrane‐Penetrating, Mannose‐Targeting Supramolecular Self‐Assembled Nanocomplexes

Author(s) -

Yin Lichen,

Song Ziyuan,

Kim Kyung Hoon,

Zheng Nan,

Gabrielson Nathan P.,

Cheng Jianjun

Publication year - 2013

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.201205088

Subject(s) - georgia tech , library science , science and engineering , nanotechnology , engineering , engineering physics , materials science , computer science , engineering ethics

Supramolecular self‐assembled nanocomplexes (SSANs) capable of mannose receptor‐mediated endocytosis and permeable to cellular and endosomal membranes are developed via the assembly of multiple rationally designed, function‐specific materials. As a unique non‐viral gene delivery vector, SSANs outperform commercial transfection reagents, including LPF2000, PEI, and jetPEI, by up to 2 orders of magnitude.

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