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Dopamine‐Melanin Colloidal Nanospheres: An Efficient Near‐Infrared Photothermal Therapeutic Agent for In Vivo Cancer Therapy
Author(s) -
Liu Yanlan,
Ai Kelong,
Liu Jianhua,
Deng Mo,
He Yangyang,
Lu Lehui
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201204683
Subject(s) - photothermal therapy , biocompatibility , materials science , melanin , nanotechnology , in vivo , biopolymer , colloid , dopamine , biomedical engineering , biophysics , polymer , chemistry , biology , medicine , biochemistry , composite material , organic chemistry , neuroscience , microbiology and biotechnology , metallurgy
A new generation of photothermal therapeutic agents based on biopolymer dopamine‐melanin colloidal nanospheres is described . Benefitting from their naturally wide distribution in humans, dopamine‐melanin colloidal nanospheres exhibit robust biocompatibility and biodegradability, and provide up to 40% photothermal conversion efficiency. After administration, they can efficiently damage tumors at low power density and short irradiation time without damaging healthy tissues.