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Ultrathin PEGylated W 18 O 49 Nanowires as a New 980 nm‐Laser‐Driven Photothermal Agent for Efficient Ablation of Cancer Cells In Vivo
Author(s) -
Chen Zhigang,
Wang Qian,
Wang Huanli,
Zhang Lisha,
Song Guosheng,
Song Linlin,
Hu Junqing,
Wang Hongzhi,
Liu Jianshe,
Zhu Meifang,
Zhao Dongyuan
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201204616
Subject(s) - photothermal therapy , materials science , in vivo , nanotechnology , ablation , tumor ablation , nanowire , laser ablation , laser , irradiation , cancer treatment , cancer , optics , medicine , physics , microbiology and biotechnology , nuclear physics , biology
A new photothermal coupling agent for photothermal ablation (PTA) therapy of tumors is developed based on ultrathin PEGylated W 18 O 49 nanowires. After being injected with the nanowire solution, the in vivo tumors exhibit a rapid temperature rise to 50.0 ± 0.5 °C upon irradiation with NIR laser light at a safe, low intensity (0.72 W cm −2 ) for 2 min (left‐hand mouse in the figure),), resulting in the efficient PTA of cancer cells in vivo in 10 min.