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Conjugated Polymer‐Coated Bacteria for Multimodal Intracellular and Extracellular Anticancer Activity
Author(s) -
Zhu Chunlei,
Yang Qiong,
Lv Fengting,
Liu Libing,
Wang Shu
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201204550
Subject(s) - conjugated system , intracellular , nanotechnology , bacteria , extracellular , materials science , polymer , chemistry , biology , biochemistry , genetics , composite material
Multifunctional cationic conjugated polyelectrolyte (CP)‐coated bacteria are fabricated for drug loading, delivery and release with multimodal anticancer activity. Facilitated by the collaborative release effect caused by CP and an antibiotic polymyxin B, the loaded toxins leak out from the vectors in considerable amounts and lead to tumor cell death. In addition, the CP coated bacterial vectors can sentisize ROS, which favors light‐mediated tumor cell killing.