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Silica‐Based Branched Hollow Microfibers as a Biomimetic Extracellular Matrix for Promoting Tumor Cell Growth In Vitro and In Vivo
Author(s) -
Qiu Penghe,
Qu Xuewei,
Brackett Daniel J.,
Lerner Megan R.,
Li Dong,
Mao Chuanbin
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201204472
Subject(s) - scaffold , materials science , microfiber , extracellular matrix , in vivo , in vitro , cancer cell , 3d cell culture , biocompatible material , nanotechnology , cell culture , matrix (chemical analysis) , biophysics , tissue engineering , biomedical engineering , microbiology and biotechnology , cancer , biology , biochemistry , composite material , medicine , genetics
A novel scaffold composed of loosely branched hollow silica microfibers that has been proven to be highly biocompatible is proposed for the 3D culture of cancer cells. The MCF‐7 cancer cells can grow and proliferate freely inside the scaffold in the form of multicellular spheroids. MCF‐7 cancer cells cultured on the current 3D silica scaffold retained significantly more oncological characters than those cultured on the conventional 2D substrate and can serve as in vitro tumor model for studying cancer treatment.