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Highly Discriminating Photorelease of Anticancer Drugs Based on Hypoxia Activatable Phototrigger Conjugated Chitosan Nanoparticles
Author(s) -
Lin Qiuning,
Bao Chunyan,
Yang Yunlong,
Liang Qiannan,
Zhang Dasheng,
Cheng Shuiyu,
Zhu Linyong
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201204455
Subject(s) - conjugated system , chitosan , nanoparticle , biophysics , materials science , drug , nanotechnology , two photon excitation microscopy , drug delivery , chemistry , biochemistry , fluorescence , biology , pharmacology , polymer , quantum mechanics , physics , composite material
An ultimately selective photorelease system of chitosan‐nanoparticles is constructed. Only under unique aspects of tumor‐hypoxia physiological conditions, the preliminary locked phototrigger is unlocked by biological reduction to enable the release of the caged drug either by visible light or two‐photon near‐IR (NIR) excitation. This approach provides a highly discriminating photorelease of anticancer drug to hypoxic tumor cells, but not to healthy normal cells.