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Degradable Terpolymers with Alkyl Side Chains Demonstrate Enhanced Gene Delivery Potency and Nanoparticle Stability
Author(s) -
Eltoukhy Ahmed A.,
Chen Delai,
Alabi Christopher A.,
Langer Robert,
Anderson Daniel G.
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201204346
Subject(s) - library science , management , computer science , economics
Degradable, cationic poly( β ‐amino ester)s (PBAEs) with alkyl side chains are developed for non‐viral gene delivery . Nanoparticles formed from these PBAE terpolymers exhibit significantly enhanced DNA transfection potency and resistance to aggregation. These hydrophobic PBAE terpolymers, but not PBAEs lacking alkyl side chains, support interaction with PEG‐lipid conjugates, facilitating their functionalization with shielding and targeting moieties and accelerating the in vivo translation of these materials.