A Robust Route to Enzymatically Functional, Hierarchically Self‐Assembled Peptide Frameworks

The addition of enzyme biofunctionality to self‐assembling peptide nanofibers is challenging since such additions can inhibit functionality or self‐assembly. We introduce a method for peptide nanofiber enzyme functionalization, demonstrated by the attachment of a polymerization synthase to peptide nanofibers. The enzyme generates a biocompatible, biodegradable biopolyester coat on the fibers with applicablity in medical engineering. This approach provides a template for generation of functional bionanomaterials.