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A Robust Route to Enzymatically Functional, Hierarchically Self‐Assembled Peptide Frameworks
Author(s) -
Sangiambut S.,
Chan K.,
Thomson N. M.,
Sato S.,
Tsuge T.,
Doi Y.,
Sivaniah E.
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201204127
Subject(s) - nanofiber , biocompatible material , peptide , nanotechnology , materials science , computer science , combinatorial chemistry , biochemistry , chemistry , biomedical engineering , engineering
The addition of enzyme biofunctionality to self‐assembling peptide nanofibers is challenging since such additions can inhibit functionality or self‐assembly. We introduce a method for peptide nanofiber enzyme functionalization, demonstrated by the attachment of a polymerization synthase to peptide nanofibers. The enzyme generates a biocompatible, biodegradable biopolyester coat on the fibers with applicablity in medical engineering. This approach provides a template for generation of functional bionanomaterials.