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Decoupling Cell and Matrix Mechanics in Engineered Microtissues Using Magnetically Actuated Microcantilevers
Author(s) -
Zhao Ruogang,
Boudou Thomas,
Wang WeiGang,
Chen Christopher S.,
Reich Daniel H.
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201203585
Subject(s) - materials science , decoupling (probability) , extracellular matrix , cell mechanics , stiffness , tissue engineering , nanotechnology , matrix (chemical analysis) , computer science , biomedical engineering , cell , composite material , engineering , control engineering , chemistry , biochemistry , cytoskeleton
A novel bio‐magnetomechanical microtissue system is described for magnetic actuation of arrays of 3D microtissues using microcantilevers. This system enables both in situ measurements of fundamental mechanical properties of engineered tissue, such as contractility and stiffness, as well as dynamic stimulation of the microtissues. Using this system, cell and extracellular matrix contributions to the tissue mechanical properties are decoupled for the first time under both static and dynamic loading conditions.