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Simple Precision Creation of Digitally Specified, Spatially Heterogeneous, Engineered Tissue Architectures
Author(s) -
Gurkan Umut Atakan,
Fan Yantao,
Xu Feng,
Erkmen Burcu,
Urkac Emel Sokullu,
Parlakgul Gunes,
Bernstein Jacob,
Xing Wangli,
Boyden Edward S.,
Demirci Utkan
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201203261
Subject(s) - photolithography , simple (philosophy) , scalability , computer science , microfabrication , nanotechnology , computer architecture , materials science , philosophy , medicine , alternative medicine , epistemology , pathology , database , fabrication
Complex architectures of integrated circuits are achieved through multiple layer photolithography, which has empowered the semiconductor industry. We adapt this philosophy for tissue engineering with a versatile, scalable, and generalizable microfabrication approach to create engineered tissue architectures composed of digitally specifiable building blocks, each with tuned structural, cellular, and compositional features.