A Sensitive H 2 O 2  Assay Based on Dumbbell‐like PtPd‐Fe 3 O 4  Nanoparticles | Zendy

Sun Xiaolian | Zendy; Guo Shaojun | Zendy; Chung ChunShiang | Zendy; Zhu Wenlei | Zendy; Sun Shouheng | Zendy

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A Sensitive H 2 O 2 Assay Based on Dumbbell‐like PtPd‐Fe 3 O 4 Nanoparticles

Author(s) -

Sun Xiaolian,

Guo Shaojun,

Chung ChunShiang,

Zhu Wenlei,

Sun Shouheng

Publication year - 2013

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.201203218

Subject(s) - nanoparticle , detection limit , dumbbell , materials science , nanotechnology , oleylamine , combinatorial chemistry , computer science , chemistry , chromatography , biology , physiology

Dumbbell‐like Pt 48 Pd 52 ‐Fe 3 O 4 nanoparticles are synthesized and functionalized with oleylamine‐polyethyleneglycol to serve as an efficient catalyst for H 2 O 2 reduction and tetramethylbenzidine (TMB) oxidation in biological solutions. The Pt 48 Pd 52 ‐Fe 3 O 4 /TMB kit is even more active than the natural enzyme for H 2 O 2 detection with a detection limit reaching 2 μM, and is successfully used to quantitatively monitor the extracellular H 2 O 2 generated by neutrophils.

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